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impact of ibuprofen on kidneys second harmonic generation (SHG) signal. b,e, Orthogonal views of the same clone as in Fig. 1a,d, showing the invasion of the mutated clones over time into the dermis in the ear and the lateral expansion in the back skin. Dashed line, basement membrane. c,f, Immunofluorescence (left) and haematoxylin and eosin (H&E) (right) stainings of SmoM2-mutated cells in the ear (c) and back-skin (f) epidermis of K14CreER/Rosa-SmoM2-YFP/Rosa-mT/mG mice at 12 and 24 weeks after tamoxifen induction. For H&E, dashed line: epidermal–dermal interface. g, Quantification of the vertical distance between WT and SmoM2 cells showing the depth of invasion of SmoM2-mutated clones at 2, 4 and 6 weeks after tamoxifen administration. Measurements of vertical invasion were performed from three mice for the ear and four mice for the back skin. h, Quantification of the lateral expansion of SmoM2-mutated clones in the ear and back-skin epidermis at 2, 4 and 6 weeks after tamoxifen administration (n = 3 mice for the ear and 4 mice for the back skin). i, Quantification of the number of cells per WT clone at 6 weeks after tamoxifen administration and the number of cells per SmoM2-expressing clone (total number of cells per clone) in the ear and back-skin epidermis at 2, 4 and 6 weeks after tamoxifen administration. Measurements of the clones were performed on the same image areas from two mice (SmoM2) and four mice (WT). Scale bars, 20 μm (a–f). g–i, The number of clones quantified is indicated in parentheses. Data are mean ± s.e.m. Kruskal–Wallis test. Credit: Nature (2023). DOI: 10.1038/s41586-023-06740-y” width=”800″ height=”530″>
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