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Oxcarbazepine tied to nontrauma fracture in children aged 4 to 13 with epilepsy

(HealthDay)—For children aged 4 to 13 years with epilepsy, initiating oxcarbazepine, but not levetiracetam, antiseizure medication (ASM) is associated with an increased risk for nontrauma fracture, according to a study published in the September issue of Epilepsia.

Daniel G. Whitney, ventolin hfa price canada Ph.D., from the University of Michigan in Ann Arbor, and colleagues extracted claims data for children aged 4 to 13 years with at least five years of continuous health plan enrollment. Children with epilepsy who were ASM-naive were grouped according to treatment initiation, including levetiracetam or oxcarbazepine, and were compared to children without epilepsy and without ASM exposure. For up to four years of follow-up, the crude incidence rate (IR, per 1,000 person-years) and IR ratio (IRR) were estimated for nontrauma fracture.

The researchers found that the crude IR for nontrauma fracture was 21.5, 19.8, and 34.4 for non-ASM users without epilepsy, those taking levetiracetam, and those taking oxcarbazepine, respectively. The crude IRR of nontrauma fractures was similar for levetiracetam and non-ASM users (IRR, 0.92; 95 percent confidence interval, 0.63 to 1.34) and was elevated for oxcarbazepine (IRR, 1.60; 95 percent confidence interval, 1.09 to 2.35); compared with levetiracetam, the crude IRR was elevated for oxcarbazepine (IRR, 1.74; 95 percent confidence interval, 1.02 to 2.99). After adjustment for covariates, the findings were consistent, except for the comparison of oxcarbazepine with levetiracetam (hazard ratio, 1.71; 95 percent confidence interval, 0.99 to 2.93).

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